We develop
cures instead of treatments
About us
Genewity is a pioneering biotech start-up focused on advanced thymus-driven therapies for immune reconstitution. Supported by the extensive business expertise of our management and advisors, we are at the forefront of developing and commercialising breakthrough therapies. With over 150 years of combined experience in immunology and gene therapy, our team is uniquely positioned to drive advancements in the field.
Mission
Our mission is to save and enhance lives by developing cutting-edge autologous gene-modified cell therapies to restore immune function in patients with immune disorders.
Vision
Our vision is to unlock the unrealised potential of restoring immune function to make a difference in the lives of patients worldwide. We pioneer innovative gene-modified cell therapies, bridging academic excellence and clinical application. By leveraging intellectual property, we transfer value and knowledge to set new industry standards with patient-centric treatments and make a global impact.
Supported by
Management & Advisors
Scientific team
Technology
Genewity is pioneering advanced technologies aimed at revolutionising immune reconstitution for patients with severe immune deficiencies. In close collaboration with world-leading institutions and industry partners, we focus on rigorous preclinical and clinical research to deliver transformative therapies that restore immune function. Our innovative solutions leverage gene-modified cell therapies to address complex immune disorders, ultimately enhancing patient well-being and healthcare outcomes. With a commitment to scientific excellence and patient-centric care, Genewity is at the forefront of transforming the future of immunotherapy.
Product pipeline
Product
undisclosed
i-Thymus
i-TOL
Indications
undisclosed
congenital athymia
undisclosed
Location
EU
EU
EU
Discovery
Preclinical
Phase I/II
Registration
trial
trial
i-Thymus
& i-TOL
Revolutionising immune reconstitution with autologous thymus tissue
For a simplified version of this explanation, click here.
The thymus is a small organ located above the heart that plays a key role in developing a balanced immune system, especially in the development of functional T-cells. Similar to SCID, for children born without a functioning thymus, even common illnesses like the flu can become life-threatening, since T-cells do not develop without the thymus. On the other hand, if the thymus promotes excessive immune activity, it can lead to autoimmune disorders, where the immune system mistakenly attacks the body's own tissues.
Unfortunately, no thymic stem cells exist to regenerate the thymus, and thymic cells cannot be cultured ex vivo. This presents a significant challenge for patients with immune dysfunctions where traditional therapeutic options are limited. At Genewity, we have developed a proprietary technology that addresses this unmet need: i-Thymus. By introducing a master transcription factor into patient-derived induced pluripotent stem cells (iPSCs), we can differentiate autologous cells into functional thymic organoids for the replacement of thymic function without the limitations of donor tissue.
The ability to generate thymic organoids from a patient’s own cells positions Genewity as a leader in the field of immune reconstitution. The i-Thymus platform offers a patient-specific solution to address immune dysfunction, targeting severeconditions (e.g. congenital athymia) where T-cell immunity needs to be switched ON, but also autoimmune diseases, where T-cell immunity needs to be switched OFF.
In autoimmune disease, we are striving to restore immune tolerance by harnessing the thymus' natural ability to induce apoptosis in auto-reactive T-cells and promote the development of regulatory T-cells. Based on the i-Thymus platform, we are creating specialised thymus tissue (i-TOL) to reprogram the patient’s immune system toward a tolerogenic state, offering a promising new avenue for treating autoimmune diseases.
For a simplified version of this explanation, click here.
The thymus is a small organ located above the heart that plays a key role in developing a balanced immune system, especially in the development of functional T-cells. Similar to SCID, for children born without a functioning thymus, even common illnesses like the flu can become life-threatening, since T-cells do not develop without the thymus. On the other hand, if the thymus promotes excessive immune activity, it can lead to autoimmune disorders, where the immune system mistakenly attacks the body's own tissues.
Unfortunately, no thymic stem cells exist to regenerate the thymus, and thymic cells cannot be cultured ex vivo. This presents a significant challenge for patients with immune dysfunctions where traditional therapeutic options are limited. At Genewity, we have developed a proprietary technology that addresses this unmet need: i-Thymus. By introducing a master transcription factor into patient-derived induced pluripotent stem cells (iPSCs), we can differentiate autologous cells into functional thymic organoids for the replacement of thymic function without the limitations of donor tissue.
The ability to generate thymic organoids from a patient’s own cells positions Genewity as a leader in the field of immune reconstitution. The i-Thymus platform offers a patient-specific solution to address immune dysfunction, targeting severeconditions (e.g. congenital athymia) where T-cell immunity needs to be switched ON, but also autoimmune diseases, where T-cell immunity needs to be switched OFF.
In autoimmune disease, we are striving to restore immune tolerance by harnessing the thymus' natural ability to induce apoptosis in auto-reactive T-cells and promote the development of regulatory T-cells. Based on the i-Thymus platform, we are creating specialised thymus tissue (i-TOL) to reprogram the patient’s immune system toward a tolerogenic state, offering a promising new avenue for treating autoimmune diseases.
Product pipeline
Product
i-Thymus
i-TOL
i-RAG
Indications
congenital athymia
undisclosed
RAG1-SCID
Location
EU
EU
EU,US
Discovery
Product pipeline
Programme
discovery-preclinical-phase1-phase2-phase3
i-Thymus
preclinical stage
i-TOL
discovery stage
News
Careers
There are currently no vacancies.
Open applications welcome
We always welcome open applications. If you are a talented individual interested in contributing to our mission, please send your CV and motivation letter to our CEO at:
a.bisschop@genewity.tech.
a.bisschop@genewity.tech.
About Genewity
Genewity B.V. is a biotechnology company based at the Leiden Bioscience Park, Netherlands, specialising in the development of advanced treatments using extracorporeal gene therapy with lentiviral vectors. This technology enables the modification of stem cell characteristics, opening new avenues for innovative gene-modified cell therapies. The company focuses on generating thymus cells from pluripotent stem cells to develop treatments for congenital athymia and autoimmune diseases.
Contact
If you have any questions, please feel free to contact us at the following email address:
info@genewity.tech